NFL Week 2 2021: Odds for each game

With the NFL regular season now officially underway, what are the odds for each game of the second week of the NFL campaign?

With Week 1 now in the rear view mirror, the NFL season is officially in full swing. As there is with every new season, the opening weekend brought us several surprises that will contribute to the odds and spreads for Week 2.

As we continue the first steps of the 2021 NFL season, let’s take a look at the betting odds for Week 2. Odds courtesy of WynnBet.

NFL Week 2 Odds

Thursday, September 16 8:20 EST,

New York Giants at Washington Football Team (-4.5), O/U 42.5

Sunday, September 19 1:00 EST

CBS: Buffalo Bills (-3.5) at Miami Dolphins, O/U 48

CBS: Denver Broncos (-6) at Jacksonville Jaguars, O/U 44

CBS: Houston Texans at Cleveland Browns (-11.5), O/U 48

CBS: New England Patriots (-3.5) at New York Jets, O/U 43

FOX: New Orleans Saints (-3) at Carolina Panthers, O/U 46

FOX: San Francisco 49ers (-3) at Philadelphia Eagles, O/U 48

FOX: Cincinnati Bengals at Chicago Bears (-3.5), O/U 45.5

CBS: Las Vegas Raiders at Pittsburgh Steelers (-6.5), O/U 48.5

FOX: Los Angeles Rams (-4) at Indianapolis Colts, O/U 47

Sunday, September 19th, 4:05 EST

FOX: Minnesota Vikings at Arizona Cardinals (-4), O/U 51

FOX: Atlanta Falcons at Tampa Bay Buccaneers (-12.5), O/U 52.5

Sunday, September 19th, 4:25 EST

CBS: Dallas Cowboys at Los Angeles Chargers (-3), O/U 52

CBS: Tennessee Titans at Seattle Seahawks (-6) O/U 52.5

Sunday, September 19th, 8:20 EST

NBC: Kansas City Chiefs (-3) at Baltimore Ravens, O/U 55.5

Monday, September 20th, 8:15 EST

ESPN: Detroit Lions at Green Bay Packers (-11), O/U 49.5

As always, there are some lines to pay attention to this week.

The Buffalo Bills are only three point favorites over the Miami Dolphins in Miami. The Bills and Josh Allen have had the Dolphins number over the last two seasons, specifically in the massacre that took place in Week 17 of last season.

The San Francisco 49ers are also just a slight favorite over the Philadelphia Eagles, as well. San Francisco begins as just three point favorites after putting up 41 points on the Detroit Lions. Eagles quarterback Jalen Hurts had a productive day against the Falcons and the Eagles handled Atlanta with ease, which could tie into the relatively close spread.

Keep in mind that if you do bet this week, bet responsibly and enjoy the weekend of NFL action.